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Cyclopamine-KAAD
Cat No.
CEI-0518
Description
Cell-permeable. A synthetic derivative of the natural product Cyclopamine that acts as a specific inhibitor of Smoothened (Smo) and Sonic hedgehog (Shh) intracellular signaling (IC₅₀ = 20 nM in the Shh-LIGHT2 assay).
Alias
KAAD-cyclopamine
Appearance
Yellow solid
Product Overview
A Smoothened (Smo) antagonist
CAS No.
306387-90-6
Molecular Weight
316.85
Purity
>98% by HPLC
Storage
-20 centigrade
Synonyms
KAAD-cyclopamine
Targets
Hh
Molecular Formula
C₄₄H₆₃N₃O₄
Chemical Name
3-Keto-N-(aminoethyl-N’-aminocaproyldihydrocinnamoyl)cyclopamine
Solubility
DMSO (100 mM) or EtOH (10 mM)
Shipping Conditions
Gel pack
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