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Cyclopamine-KAAD

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Cat No.

CEI-0518

Description

Cell-permeable. A synthetic derivative of the natural product Cyclopamine that acts as a specific inhibitor of Smoothened (Smo) and Sonic hedgehog (Shh) intracellular signaling (IC₅₀ = 20 nM in the Shh-LIGHT2 assay).

Alias

KAAD-cyclopamine

Appearance

Yellow solid

Product Overview

A Smoothened (Smo) antagonist

CAS No.

306387-90-6

Molecular Weight

316.85

Purity

>98% by HPLC

Storage

-20 centigrade

Synonyms

KAAD-cyclopamine

Targets

Molecular Formula

C₄₄H₆₃N₃O₄

Chemical Name

3-Keto-N-(aminoethyl-N’-aminocaproyldihydrocinnamoyl)cyclopamine

Solubility

DMSO (100 mM) or EtOH (10 mM)

Shipping Conditions

Gel pack