CX-4945, a golden colored solid material, is a potent, selective, and ATP-competitive inhibitor of both isoforms of the CK2 catalytic subunits CK2alpha and CK2alpha with IC50 values of 1 nM. Protein kinase CK2, also known as casein kinase-2, is a pleiotropic, highly conserved serine/threonine protein kinase ubiquitously expressed in both the cytoplasm and the nucleus of eukaryotic cells. And its involved in cell growth, proliferation and suppression of apoptosis.
In vivo
CX-4945 inhibited prosurvival and angiogenic signaling in cancer cell lines and exhibited antitumor activity in murine xenografts.
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