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CX-4945
Cat No.
CEI-0311
Description
CX-4945 can inhibit CK2alpha and CK2alpha with IC50 of 1 nM and 1 nM.
CAS No.
1009820-21-6
Molecular Weight
349.77
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
CK2alpha
Molecular Formula
C19H12ClN3O2
Chemical Name
5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid
Solubility
DMSO 16 mg/mL Water
In vitro
CX-4945, a golden colored solid material, is a potent, selective, and ATP-competitive inhibitor of both isoforms of the CK2 catalytic subunits CK2alpha and CK2alpha with IC50 values of 1 nM. Protein kinase CK2, also known as casein kinase-2, is a pleiotropic, highly conserved serine/threonine protein kinase ubiquitously expressed in both the cytoplasm and the nucleus of eukaryotic cells. And its involved in cell growth, proliferation and suppression of apoptosis.
In vivo
CX-4945 inhibited prosurvival and angiogenic signaling in cancer cell lines and exhibited antitumor activity in murine xenografts.
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