Description
Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.
Abbr
Cucurbitacin I(STAT3, JAK2)
Stability
Stable under recommended storage conditions.
Molecular Formula
C30H42O7
Chemical Name
(9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
Solubility
Soluble to 10 mM in DMSO and to 20 mM in ethanol