Description
Crizotinib (PF-02341066) can inhibit c-Met and ALK with IC50 of 11 nM and 24 nM.
Storage
2 years at -20centigrade Powder
Molecular Formula
C21H22CL2FN5O
Chemical Name
3-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
Solubility
DMSO 20 mg/mL Water
In vitro
As an ATP-competitive, small-molecule inhibitor, crizotinib (PF-02341066), c-Met (also known as hepatocyte growth factor receptor) and anaplastic lymphoma kinase (ALK).Crizotinib inhibited the growth and survival of cell lines dependent upon c-Met or ALK enzymatic activity.Crizotinib has been particularly effective against anaplastic large cell lymphoma and non-small cell lung cancer (NSCLC) cell lines, and that NSCLC cell lines harbors ALK translocations which would lead to expression of oncogenic ALK fusion proteins.
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