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Compound E
Cat No.
CEI-0707
Description
Cell-permeable. A potent, selective, non-transition state and non-competitive inhibitor of γ-secretase (IC50 = 0.3 nM for total β-amyloid) and Notch processing. At higher concentrations (20-400 µM), only weakly affects the presenilase activity.
Appearance
White solid
Product Overview
A potent, selective inhibitor of γ-secretase
CAS No.
209986-17-4
Molecular Weight
465.76
Purity
>85% by HPLC
Storage
-20 centigrade
Targets
gamma-secretase
Molecular Formula
C₂₇H₂₄F₂N₄O₃
Chemical Name
(2S)-2-([(3,5-Difluorophenyl)acetyl]amino)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide
Solubility
10 mM HCl
Shipping Conditions
Gel pack
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