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Combretastatin A4
Cat No.
CEI-0566
Description
A vascular disrupting, antineoplastic and microtubule-depolymerizing agent. Binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, it disrupts the engagement of the endothelial cell–specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and thus the activity of the VE-cadherin/β-catenikt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation.
Alias
CRC 87-09, NSC 817373
Appearance
Crystalline solid
Product Overview
A vascular disrupting, antineoplastic and microtubule-depolymerizing agent.
CAS No.
117048-59-6
Molecular Weight
376.41
Purity
>99% by HPLC
Storage
-20 centigrade
Synonyms
CRC 87-09, NSC 817373
Targets
Microtubule
Molecular Formula
C 18 H 20 O 5
Chemical Name
2-Methoxy-5-[(1Z)-2-(3,4,5-trimetho-xyphenyl)ethenyl]phenol
Solubility
DMSO (38 mg/ml)
Shipping Conditions
RT
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