CELBrase-001 contains highly purified collagenase class I and class II with a medium concentration of highly purified thermolysin. The two collagenase isoforms are from clostridium histolyticum and blended in a precise ratio with each other. Thermolysin is a neutral protease isolated from Bacillus thermoproteolyticus. The blend is manufactured in accordance with Good Manufacturing Practice (GMP).