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CL075
Cat No.
LIGC-007
Description
CL075 is a thiazoloquinolone derivative that stimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-κB and triggers preferentially the production of TNF-α and IL-12. CL075 seems also to induce the secretion of IFN-α through TLR7 but to a lesser extend. It induces the activation of NF-κB at 0.4 µM (0.1 µg/ml) in TLR8-transfected HEK293 cells, and ~ 10 times more CL075 is required to activate NF-κB in TLR7-transfected HEK293 cells.
Appearance
Yellow lyophilized powder
Molecular Weight
243.33
Concentration
Working Concentration:
0.1 - 5 μg/ml CL075 for human TLR8 and mouse TLR7
0.5 - 5 μg/ml CL075 for human TLR7
0.1 - 5 μg/ml CL075 for human TLR8 and mouse TLR7
0.5 - 5 μg/ml CL075 for human TLR7
Specificity
human TLR7/8 and mouse TLR7 agonist
Stability
Lyophilized product is stable 1 year at -20°C when properly stored. Resuspended CL075 should be aliquoted and stored at -20°C. Resuspended product is stable 6 months at -20°C. Avoid repeated freeze-thaw cycles.
Storage
Store at -20°C.
Molecular Formula
C13H13N3S
Solubility
1 mg/ml in water
Endotoxin Level
<0.001 EU/µg
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