Description
Ciproxifan can potently inhibit H3-receptor with IC50 of 9.2 nM.
Storage
2 years -20centigrade Powder
Molecular Formula
C16H18N2O2.C4H4O4
Chemical Name
cyclopropyl-(4-(3-1H-imidazol-4-yl)propyloxy) phenyl) ketone
Solubility
DMSO 54 mg/ml, Water 1 mg/ml, Ethanol 54 mg/ml
In vitro
Ciproxifan is a novel chemical series of histamine H3-receptor antagonist.Ciproxifan can potently inhibit H3-receptor with IC50 of 9.2 nM. In vitro, ciproxifan is a competitive antagonist at the H3 autoreceptor controlling [3H]histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with [125I]iodoproxyfan. Ciproxifan displayed at least 3-orders of magnitude lower potency at various aminergic receptors studied in functional or binding tests.
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