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CHR-6494
Cat No.
CEI-1280
Product Overview
Haspin is a serine/threonine kinase that phosphorylates Thr-3 of histone H3 in mitosis that has emerged as a possible cancer therapeutic target. CHR-6494 is a first-in-class Haspin inhibitor with a wide spectrum of anticancer effects. Recent research showed that CHR-6494 reduces H3T3ph levels in a dose-dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification. From the cellular standpoint, the identified small-molecule Haspin inhibitor causes arrest in G2/M and subsequently apoptosis. Importantly, ex vivo assays also demonstrate its anti-angiogenetic features; in vivo, it shows antitumor potential in xenografted nude mice without any observed toxicity.
CAS No.
1333377-65-3
Molecular Weight
292.34
Purity
0.98
Storage
Store at -20°C
Synonyms
CHR 6494; CHR6494
Targets
Haspin
Molecular Formula
C16H16N6
Chemical Name
3-(1H-indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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