Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
CHIR-99021(CT99021)
Cat No.
CEI-0123
Description
CT99021(CHIR-99021) can inhibit GSK3alpha and GSK3beta with IC50 of 10 nM and 6.7 nM.
CAS No.
252917-06-9
Molecular Weight
465.34
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
GSK3alpha, GSK3beta
Molecular Formula
C22H18Cl2N8
Chemical Name
6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino)ethylamino)nicotinonitrile hydrochloride
Solubility
DMSO 100 mg/mL Water 100 mg/mL Ethanol 20 mg/mL
In vitro
As a potent inhibitor, CT99021(CHIR-99021) can inhibit GSK3alpha and GSK3beta with IC50 of 10 nM and 6.7 nM. Inhibition of GSK3 with CT99021 (3 microM) resulted in a significant increase in the percentage and quality of blastocysts. CT99021 can reduced the phosphorylation of beta-catenin on Ser45 in two-cell embryos.
Download
Download Datasheet