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Chidamide
Cat No.
CEI-0504
Description
Cell-permeable. A new benzamide class of histone deacetylase (HDAC) inhibitor with marked anti-tumor activity. It increases histone H3 acetylation levels in LoVo and HT29 colon cancer cells at concentrations as low as 4 µM. Additionally, chidamide affects the activation of oncogenic signaling kinases by dose-dependently reducing phosphorylated Akt, mTOR, p70S6k, Raf, and Erk1/2 protein expression in colon cancer cells.
Appearance
White solid
Product Overview
A potent histone deacetylase inhibitor
CAS No.
743420-02-2
Molecular Weight
382.45
Purity
>95% by HPLC
Storage
-20 centigrade
Targets
HDAC
Molecular Formula
C22H19FN4O2
Chemical Name
N-(2-amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-benzamide
Solubility
DMSO (200 mM)
Shipping Conditions
Gel pack
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