Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
c-FMS inhibitor
Cat No.
CEI-1275
Description
c-FMS inhibitor is a potent, orally active and small-molecule inhibitor of FMS kinase with IC50 value of 0.8 nM.
Product Overview
c-FMS inhibitor, 4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl) phenyl]-1H-pyrrole-2-carboxamide, is a novel FMS kinase inhibitors as anti-inflammatory agents with an IC50 value of 0.8 nM. c-FMS inhibitor resulted in identification of a highly potent series of 2,4-disubstituted arylamides. It served as a proof-of-concept candidate in a collagen-induced model of arthritis in mice. c-FMS inhibitors has a potential to form reactive metabolites which are transformed into a series with equivalent potency by incorporation of carbon-based replacement groups. Structure-based model provides the framework to efficiently effect this transformation and restore potencies to previous levels. This optimization removed a risk factor for potential idiosyncratic drug reactions.
CAS No.
885704-21-2
Molecular Weight
406.52
Purity
0.98
Storage
Store at -20°C
Synonyms
1H-Pyrrole-2-carboxamide
Targets
FMS kinase
IC50
0.8 nM
Molecular Formula
C23H30N6O
Chemical Name
4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl)phenyl]-1H-pyrrole-2-carboxamide
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
Download
Download Datasheet