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Cerubidine(Daunorubicin)
Cat No.
CEI-0273
Description
Cerubidine
Alias
daunorubicin hydrochloride
CAS No.
23541-50-6
Molecular Weight
563.98
Purity
>99%
Storage
2 years at --20centigrade Powder
Synonyms
daunorubicin hydrochloride
Targets
Topoisomerase II
Molecular Formula
C27H29NO10.HCl
Chemical Name
(7S,9R)-9-acetyl-7-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-6,9, 11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5, 12-dione;hydrochloride
Solubility
DMSO 113 mg/mL, Water 113 mg/mL, Ethanol 13 mg/mL
In vitro
At drug concentrations that reflect the peak plasma concentration after Daunorubicin administration, the primary mechanism is likely to be through interaction with topoisomerase II, which may be a primary triggering event for growth arrest and/or cell killing through a signalling pathway leading to apoptosis, at least in leukemic cells and thymocytes. The quinone structure permits daunorubicin to act as electron acceptors in reactions mediated by oxoreductive enzymes including cytochrome P450 reductase, NADH dehydrogenase, and xanthine oxidase.
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