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Cercosporamide
Cat No.
CEI-1076
Description
Potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Blocks eIF4E phosphorylation; exhibits antiproliferative and proapoptotic activity in cancer cells in vitro. Also inhibits Pkc1. Orally bioavailable.
Abbr
Cercosporamide(MKNK2, JAK3, MKNK1)
Alias
GPRK7, MNK2
CAS No.
131436-22-1
Molecular Weight
331.28
Purity
>96 %
Stability
Stable under recommended storage conditions.
Storage
-20 centigrade
Synonyms
GPRK7, MNK2
Targets
Mnk2, JAK3, Mnk1
IC50
11nM, 31nM, 116 nM
Molecular Formula
C16H13NO7
Chemical Name
(9aS)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancaboxamide
Solubility
Soluble to 10 mM in DMSO
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