Description
A synthetic peptide inhibitor that irreversibly inhibits caspase-3 and related protease/caspase activity and blocks apoptosis. DEVD is the specific recognition sequence found in poly (ADP-ribose) polymerase (PARP). The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Alias
Z-DEVD-FMK, Caspase-4 inhibitor (fluoromethylketone)
Appearance
Pale yellow solid
Product Overview
Caspase-3 inhibitor
Synonyms
Z-DEVD-FMK, Caspase-4 inhibitor (fluoromethylketone)
Molecular Formula
C₃₀H₄₁FN₄O₁₂
Solubility
DMSO (~30 mg/ml) or H₂O (~ 31 mg/ml)
Shipping Conditions
Gel pack
Amino Acid Sequence
Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK
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