Description
Reversibly inhibits nuclear topoisomerase I by binding to and stabilizing the topoisomerase-DNA covalent complex. Inhibits Tat-mediated transcription of HIV-1. Induces apoptosis in Jurkat, osteosarcoma and hepatoma cells.
Product Overview
A topoisomerase I inhibitor
Molecular Formula
C₂₀H₁₆N₂O₄
Chemical Name
(S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione
Solubility
A 10 mM (1 mg in 195 µl) solution of caspase inhibitor Q-VD-OPh in DMSO.
Shipping Conditions
Gel pack
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