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C646, p300/CBP Inhibitor

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Cat No.

CEI-0599

Description

Cell-permeable. A reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor (Ki = 400 nM). Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (<10%). Suppresses histone H3 and H4 acetylation in mouse fibroblast cell lines.

Appearance

White solid

Product Overview

A reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor

CAS No.

328968-36-1

Molecular Weight

503

Purity

>98% by TLC

Storage

-20 centigrade

Targets

EP300, CREBBP

Molecular Formula

C₂₄H₁₉N₃O₆

Chemical Name

(E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

Solubility

DMSO

Shipping Conditions

Gel pack