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BX-912

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Cat No.

CEI-0085

Description

As a selective inhibitor, BX912 can potently inhibit PDK1 with IC50 of 12 nM.

CAS No.

702674-56-4

Molecular Weight

471.35

Purity

>99%

Storage

2 years at -20 centigrade

Targets

PDK1

Molecular Formula

C20H23BrN8O

Chemical Name

N-(3-(4-(2-(1H-imidazol-5-yl)ethylamino)-5-bromopyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide

Solubility

DSMO 94 mg/mL Water

In vitro

BX912 prevents ChcK1, PKA, c-kit, and KDR with IC50 of 0.83, 0.11, 0.85, and 0.41 uM, resepectively. BX912 blocks PDK1/Akt signaling in tumor cells and suppresses the anchorage-dependent growth of a variety of tumor cell lines (such as PC-3 cells ) in culture or induces apoptosis.BX912 also potently inhibits the growth of HCT-116 cells in soft agar, showing a 96% inhibitory effect at a dose of 1 uM. BX912 potently inhibits the growth of PC-3 cells in soft agar, displaying IC50 of 0.32 uM.