Description
Trypsinogen is a substance that is normally produced in the pancreas and released into the small intestine. it is a proenzyme (zymogen) that is activated to form trypsin. Bovine trypsinogen consists of 229 amino acids and contains 6 pairs of disulfide bonds. Under the catalysis of enterokinase, the peptide bond between the N-terminal lysine and isoleucine residues of the trypsinogen is hydrolyzed to release peptide, producing active trypsin called β-trypsin, which undergoes autolysis at Lys131 - Ser132 resulting in α-trypsin. Once activated, the trypsin can cleave more trypsinogen into trypsin, a process called autoactivation.
Download Datasheet