Storage
2 years at -20centigrade Powder
Targets
CDK1/cyclin B, CDK2/cyclin E
Molecular Formula
C18H17F2N3O2
Chemical Name
(4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-(2, 6-difluoro-4-methylphenyl)methanone
Solubility
DMSO 20 mg/mL, Water
In vitro
BMS265246 can potently inhibit CDK1/cyclin B and CDK2/cyclin E with IC50 of 6 nM and 9 nM. BMS265246 which binds to CDK2 shows the inhibitor resides coincident with the ATP purine binding site and forms important H-bonds with Leu83 on the protein backbone. BMS265246 exhibits CDK1 and CDK2 potency that is 25- and 11-fold more potent versus CDK1 and CDK2, respectively.
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