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BML-277

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Cat No.

CEI-0960

Description

A highly selective inhibitor of Chk2 (IC50=15 nM). Displays <25% inhibition of 35 other kinases at 10 uM). It possesses potent radioprotective activity and prevents apoptosis of human T-cells subjected to ionizing radiation (EC50= 3-7.6 μM). It is a useful tool for determining the role of Chk2 in cellular signaling.

Abbr

BML-277(CHEK2)

Alias

2-(4-(4-chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide, Chk2 Inhibitor II

Appearance

Off white solid

Product Overview

CHK2 inhibitor

CAS No.

516480-79-8

Molecular Weight

363.8

Purity

>98% (TLC; 1:1 ethylacetate: hexane; Rf=0.17); NMR (Conforms)

Synonyms

2-(4-(4-chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide, Chk2 Inhibitor II

Targets

CHK2

Molecular Formula

C20H14ClN3O2

Solubility

May be dissolved in DMSO (20 mg/ml); or Ethanol (20 mg/ml)

"CHEK2" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-0122	Checkpoint Kinase 2, Active Human, Recombinant			E. coli	Inquiry