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BIX 02189
Cat No.
CEI-0152
Description
As a selective inhibitor, BIX02189 can inhibit MEK5 with IC50 of 1.5 nM.
CAS No.
1094614-85-3
Molecular Weight
440.54
Purity
>99%
Storage
2 years at -20 centigrade
Targets
MEK5
Molecular Formula
C27H28N4O2
Chemical Name
(Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide
Solubility
DSMO 88 mg/mL Water
In vitro
BIX02189 can inhibit MEK5 and ERK5 catalytic activity with IC50 values of 1.5 nM and 59 nM, respectively. They are more potent than the effect caused by BIX02188 with IC50 values of 4.3 nM and 830 nM. BIX02189 (10 uM) inhibits ERK5 phosphorylation, and reduces myocyte enhancer factor 2 (MEF2) transcriptional activity in neonatal rat cardiomyocytes (NRCMs) stimulated by isoproterenol.
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