Description
A synthetic peptide that irreversibly inhibits activity of caspase-8 and related caspases and blocks apoptosis. The inhibitor is designed as a methyl ester to enhance cell permeability. The conjugation with biotin allows detection of activated caspases in conjunction with avidin-tags. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Alias
Biotin-IETD-FMK, IETD-FMK, Biotin-
Appearance
White to off-white solid
Product Overview
A Caspase-8 inhibitor
Synonyms
Biotin-IETD-FMK, IETD-FMK, Biotin-
Molecular Formula
C₃₈H₆₂FN₇O₁₂S
Solubility
DMSO (~ 15 mg/ml) or Ethanol (~ 10 mg/ml)
Shipping Conditions
Gel pack
Amino Acid Sequence
Biotin-Ile-Glue(OMe)-Thr-Asp(OMe)-FMK
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