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bile acid CoA-transferase
Cat No.
EXWM-3421
Description
The enzyme, characterized from the gut bacterium Clostridium scindens, catalyses the last step in bile acid 7α-dehydroxylation, the removal of the CoA moiety from the products. By using a transferase rather than hydrolase, the bacteria conserve the thioester bond energy, saving ATP molecules. Clostridium scindens possesses two forms of the enzyme, encoded by the baiF and baiK genes. While the enzymes have a broad acceptor specificity and can use allocholate, ursodeoxycholate, and β-muricholate, the donor specificity is more strict. BaiF acts on lithocholoyl-CoA and deoxycholoyl-CoA, and BaiK acts only on the latter.
Form
Liquid or lyophilized powder
Enzyme Commission Number
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
Synonyms
baiF (gene name); baiK (gene name); bile acid coenzyme A transferase
Reaction
(1) lithocholoyl-CoA + cholate = lithocholate + choloyl-CoA; (2) deoxycholoyl-CoA + cholate = deoxycholate + choloyl-CoA
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
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