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Belinostat (PXD101)
Cat No.
CEI-1242
Description
Belinostat (PXD101) is a novel inhibitor of pan-HDAC with an IC50 value of 27 nM.
Product Overview
Belinostat (also known as PXD101) is a novel and potent hydroxamate-type inhibitor of histone deacetylase (HDAC) that inhibits the activity of HDAC in Hela cell extracts with 50% inhibition concentration IC50 value of 27 nM. Belinostat has been found to significantly increase the acetylation of histones H3 and H4 and exerts cytotoxicity in a wide range of tumor cell lines. In the treatment of urothelial carcinoma cell lines, belinostat dose-dependently inhibits proliferation in 5637, T24, J82 and RT4 cells with IC50 values of 1.0 μM, 3.5 μM, 6.0 μM and 10 μM respectively; while, in prostate cancer cell lines, it inhibits cancer cell growth with IC50 values ranging from 0.5 to 2.5 μM.
CAS No.
414864-00-9
Molecular Weight
318.35
Purity
0.991
Storage
Store at -20°C
Synonyms
PXD-101, PXD 101, PX105684, PX-105684
Targets
HDAC
IC50
27 nM
Molecular Formula
C15H14N2O4S
Chemical Name
(E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide
Solubility
Soluble in DMSO > 10 mM
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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