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BCX 1470 methanesulfonate
Cat No.
CEI-1241
Product Overview
BCX 1470 is a serine protease inhibitor with the IC50 of 96 nM for factor D and 1.6 nM for C1s. Serine proteases are enzymes that cleave peptide bonds in proteins which are found ubiquitously in both eukaryotes and prokaryotes and serine serves as the nucleophilic amino acid at the active site. According to structure, serine proteases are divided into trypsin-like (chymotrypsin-like) family and subtilisin-like family. It is reported that serine proteases play an important role in various physiological functions, including digestion, immune response, blood coagulation and reproduction. BCX 1470 is a potent serine protease inhibitor and functions on the complement enzymes CIs and factor D sites. By determining the ability of enzyme to hydrolyze appropriate synthetic substrates, the result showed that BCX 1470 inhibited the factor D and C1s esterolytic activity which were important in the function of serine protease. In induced dermal RPA reaction rat model, administration of BCX 1470 markedly abbrogated the RPA reaction via inhibiting edema development and complement activity by inactivation of C1s and factor D enzymatic activity. It is also reported that BCX 1470 inhibited Trypsin with the IC50 value of 326 nM.
CAS No.
217099-44-0
Molecular Weight
398.48
Purity
0.98
Storage
Store at -20°C
Synonyms
BCX 1470; BCX-1470; BCX1470
Targets
Serine protease
Molecular Formula
C15H14N2O5S3
Chemical Name
(2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate; methanesulfonic acid
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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