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Bay 65-1942 free base
Cat No.
CEI-1237
Product Overview
Bay 65-1942 free base is a selective inhibitor of IKKβ with IC50 value of 10 μM and Ki value of 2 nM. IKKβ (inhibitor of nuclear factor kappa-B kinase subunit beta) is a subunit of Iκ B kinase which regulates the NF-κ B activation and plays an important role in triggering immune responses. Bay 65-1942 is a potent IKKβ inhibitor. When tested with MYL-R cells, administration of Bay 65-1942 reduced cell viability and induced cell apoptosis by decreasing IKKβ expression. In human alveolar type II epithelium-like lung adenocarcinoma cell line A549, treatment of Bay 65-1942 inhibited IKKβ -dependent signal transduction and NF-κ B activation by inhibiting IKKβ. In acute ischemia-reperfusion C57BL/6 mice model, administration of Bay 65-1942 significantly reduced left ventricular infarct size and preserved cardiac function and finally prevented cardiac injury following IR by inhibiting IKK&beta
CAS No.
600734-02-9
Molecular Weight
395.45
Storage
Store at -20°C
Targets
IKKβ kinase
Molecular Formula
C22H25N3O4
Chemical Name
(7E)-7-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-5-[(3S)-piperidin-3-yl]-4,8-dihydro-1H-pyrido[2,3-d][1,3]oxazin-2-one
Solubility
DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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