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BAY 11-7082
Cat No.
CEI-0590
Description
Potential anti-inflammatory agent. Selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation. Inhibits the TNF-α-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells with IC50 values of 5-10 µM.
Appearance
Colorless film
Product Overview
A NF-κB activation inhibitor
CAS No.
19542-67-7
Molecular Weight
622.84
Purity
>95% by HPLC
Storage
-20 centigrade
Targets
NFKB1
Molecular Formula
C₁₀H₉NO₂S
Chemical Name
(E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile
Solubility
DMSO
Shipping Conditions
Gel pack
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