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BAN ORL 24
Cat No.
CEI-1234
Product Overview
BAN ORL24 is a selective inhibitor of NOP with pK(i) value of 9.62. NOP (nociceptin/orphanin FQ (N/OFQ) peptide receptor) is a G protein coupled receptor and plays an important role in regulating many brain activities. BAN ORL24 is a potent NOP inhibitor and has the highest affinity compared with other NOP inhibitors. When tested with CHO (hNOP) cells, administration of BAN ORL24 showed high affinity to cell membrane and higher selective compared with classical opioid receptors. In SG neuron heterologously expressing NOP receptors with an enhanced basal facilitation ratio, BAN ORL24 treatment for 50 seconds enhanced the Ca2+ current amplitude for both prepulse and postpulse. In the mouse tail withdrawal assay, administration of BAN ORL24 (10 mg/kg) combined with N/OFQ (1 nmol) antagonized the pronociceptive and antinociceptive effects of given supraspinally and spinally, respectively. Under the same experimental conditions BAN ORL24 did not affect the antinociceptive action of 3 nmol endomorphin-1 injected intrathecally
CAS No.
475150-69-7
Molecular Weight
506.51
Purity
0.98
Storage
Store at -20°C
Synonyms
BAN-ORL-24; BAN ORL-24
Targets
NOP receptor
Molecular Formula
C27H37Cl2N3O2
Chemical Name
(2R)-1-benzyl-N-(3-spiro[1H-2-benzofuran-3,4-piperidine]-1-ylpropyl)pyrrolidine-2-carboxamide; dihydrochloride
Solubility
Soluble in DMSO > 10 mM
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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