Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
AZD8330
Cat No.
CEI-0147
Description
AZD8330 can inhibit MEK1/2 with IC50 of 7nM.
CAS No.
869357-68-6
Molecular Weight
461.23
Purity
>99%
Storage
2 years at -20 centigrade
Targets
MEK1/2
Molecular Formula
C16H17FIN3O4
Chemical Name
2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
Solubility
DSMO 92 mg/mL Water
In vitro
AZD8330 (ARRY-424704),a potent and selective uncompetitive inhibitor, can inhibit MEK1/2 with IC50 of 7 nM and shows inhibition to ERK phosphorylation in Malme-3M cells with IC50 of 0.4 nM.AZD8330 (ARRY-424704) shows sub-nM inhibition of Ras/Raf/MEK/ERK signaling in tumor cell lines and low to sub-nM potency in functional (proliferation) assays in MEK 1/2 inhibitor sensitive cell lines. AZD8330 (ARRY-424704) also inhibit HT29 cell viability, Calu-6 cell viability, and Colo205 cell viability with IC50 of 3.8 nM, 11 nM and 0.7 nM. In tumor cell line panels AZD8330 demonstrates a similar pattern of activity with respect to BRAF and RAS gene mutation status to other MEK 1/2 inhibitors (AZD6244 and PD-0325901).
In vivo
In two nude rat human tumor xenograft models, AZD8330 (oral doses:0.4 mg/kg) shows significant anti-tumor efficacy.
Download
Download Datasheet