Description
AZD1480 can inihbit JAK1 and JAK2 with IC50 of 1.3 nM and 0.4 nM.
Storage
2 years at -20centigrade Powder
Molecular Formula
C14H14ClFN8
Chemical Name
(S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Solubility
DMSO 70 mg/mL Water
In vitro
AZD1480 is a novel pyrazol pyrimidine ATP-competitive inhibitor of JAK1 and JAK2 kinases, with IC50s of 1.3 and 0.4 nM. AZD1480 inhibits constitutive and IL-6 induced STAT-3 activation and subsequent nuclear translocation.
In vivo
AZD1480 shows inhibition to solid tumor, including breast, ovarian, and prostate. AZD1480 inhibits the STAT3 phosphorylation in vitro and in an in vivo xenograft model of human solid tumors and multiple myeloma.
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