Description
Aurora A kinase also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene. Aurora A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation. Aurora A is activated by one or more phosphorylations and its activity peaks during the G2 phase to M phase transition in the cell cycle.
Abbr
ARK1, Recombinant (Human)
Alias
ARK1; AURA; BTAK; STK6
Source
baculovirus infected Sf9 cells
Applications
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Package
Minimum 50 ng protein/vial by Bradford
Product Overview
Human Aurora kinase A (GenBank Accession No. NM_003600), amino acids 2-403 with N-terminal HIS6-tag, MW=50 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Activity
~17,000 units/mg protein
Molecular Weight
mol wt 50 kDa
Unit Definition
One unit is defined as the amount of enzyme that will phosphorylate 1 pmol of Ser/Thr 1 peptide substarte per minute at pH 7.4 and 30°C.
Synonyms
Aurora Kinase A; Aurora A kinase; serine/threonine-protein kinase 6; AURKA; AIK; ARK1; AURA; AURORA2; BTAK; PPP1R47; STK15; STK6; STK7
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