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Auranofin
Cat No.
CEI-0552
Description
An anti-arthritic drug that inhibits various leukocyte activation pathways at multiple sites. Inhibits release of inflammatory mediators from human basophils, pulmonary mast cells and macrophages. Also inhibits human neutrophil 5-lipoxygenase. Inhibits IκB kinase (IKK) by modifying Cys179 of the IKKß subunit. Efficient inducer of mitochondrial membrane permeability transition via the inhibition of mitochondrial thioredoxin reductase (TrxR).
Alias
SKF39162
Appearance
Red solid
Product Overview
Leukocyte activation pathways inhibitor
CAS No.
34031-32-8
Molecular Weight
445.42
Purity
>98% by NMR
Storage
-20 centigrade
Synonyms
SKF39162
Targets
Leukocyte activation pathways
Molecular Formula
C20H34AuO9PS
Chemical Name
1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate
Solubility
DMSO (25 mM)
Shipping Conditions
Gel pack
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