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asparagine synthase (glutamine-hydrolysing)
Cat No.
EXWM-5807
Description
The enzyme from Escherichia coli has two active sites that are connected by an intramolecular ammonia tunnel. The enzyme catalyses three distinct chemical reactions: glutamine hydrolysis to yield ammonia takes place in the N-terminal domain. The C-terminal active site mediates both the synthesis of a β-aspartyl-AMP intermediate and its subsequent reaction with ammonia. The ammonia released is channeled to the other active site to yield asparagine.
Form
Liquid or lyophilized powder
Enzyme Commission Number
CAS No.
37318-72-2
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
Synonyms
asparagine synthetase (glutamine-hydrolysing); glutamine-dependent asparagine synthetase; asparagine synthetase B; AS; AS-B
Reaction
ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate (overall reaction); (1a) L-glutamine + H2O = L-glutamate + NH3; (1b) ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
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