Description
AS-605240 is a high selective inhibitor of PI3K-gamma with IC50 of 8 nM.
Storage
2 years at -20 centigrade
Molecular Formula
C12H7N3O2S
Chemical Name
(Z)-5-(quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
Solubility
DSMO 0.4 mg/mL Water
In vitro
AS-605240 is an ATP-competitive PI3Kgamma inhibitor, with Ki values of 7.8 nM. AS-605240 is isoform-selective, for AS-605240 also inhibits PI3Kalpha, beta, and delta, with IC50 of 60, 270, and 300 nM, respectively.
In vivo
In a alphaCII-induced arthritis, AS-605240 (50 mg/kg) protects against alphaCII-IA symptom.In an obesity-induced diabetes model (ob/ob mice), AS-605240 (10 mg/kg) lowers blood glucose levels, significantly improves both insulin sensitivity and glucose tolerance without affecting body weight.
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