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AS-604850

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Cat No.

CEI-0100

Description

AS-604850

CAS No.

648449-76-7

Molecular Weight

285.22

Purity

>99%

Storage

2 years at -20 centigrade

Targets

PI3K-gamma

Molecular Formula

C11H5F2NO4S

Solubility

In vitro

AS-604850 is capable of inhibiting C5a-mediated PKB phosphorylation in RAW264 mouse macrophages with an IC50 with 10 uM. AS-604850 blocks MCP-1-mediated chemotaxis in Pik3cg +/+ monocytes in a concentration- dependent manner, with an IC50 of 21 mM, but dosnt affect chemotaxis in Pik3cg-/- cells, indicating that AS-604850 acts through PI3K-gamma.