Description
ARQ 197 (Tivantinib) can inhibit c-Met with IC50 of 100 nM
Storage
2 years at -20 centigrade
Molecular Formula
C23H19N3O2
Chemical Name
(3R,4R)-3-(2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-6-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
Solubility
DSMO 74 mg/mL Water
In vitro
Tivantinib, an oral, non-ATP competitive, selective c-MET inhibitor. Treatment of cells with tivantinib resulted in a comparable concentration-dependent decrease in cell viability with GI 50 values of 1.2 and 3.7 mmol/L obtained in MDA-MB-231/TGL and 1833/TGL cells,
In vivo
Treatment with tivantinib at the doses of 60 and 120 mg/kg induced a dose-dependent delay and a reduction of bone metastatic growth.
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