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Apremilast

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Cat No.

CEI-0616

Description

Apremilast is a potent PDE4 (phosphodiesterase 4) inhibitor (IC50 = 74 nM). It reduces TNF-α production in human synovial cells and significantly suppresses experimental arthritis.

Appearance

Yellow solid

Product Overview

A potent PDE4 (phosphodiesterase 4) inhibitor

CAS No.

608141-41-9

Molecular Weight

602.8

Purity

>95% by TLC

Storage

-20 centigrade

Targets

PDE1a, PDE2A, PDE3A, PDE4A, PDE5A

Molecular Formula

C 22 H 24 N 2 O 7 S

Chemical Name

N-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide

Solubility

DMSO (25 mg/ml) or EtOH (25 mg/ml)

Shipping Conditions

Gel pack

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-0521	Phosphodiesterase 3A from Human, Recombinant	EC 3.1.4.17	9040-59-9	Sf9 cells	Inquiry