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Apixaban
Cat No.
CEI-0241
Description
As a highly selective, reversible inhibitor, apixaban can inhibit Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.
CAS No.
503612-47-3
Molecular Weight
459.5
Purity
>99%
Storage
2 years at -20 centigrade
Targets
Factor Xa
Molecular Formula
C25H25N5O4
Chemical Name
1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Solubility
DSMO 18 mg/mL Water
In vitro
Apixaban exhibits a high degree of potency, selectivity, and efficacy on Factor Xa with Ki of 0.08 nM and 0.17 nM for Human Factor Xa and Rabbit Factor Xa. And Apixaban shows the highest potency in human and rabbit plasma.
In vivo
In the arteriovenous-shunt thrombosis (AVST), venous thrombosis (VT) and electrically mediated carotid arterial thrombosis (ECAT) rabbit models, Apixaban produces dose-dependent antithrombotic effects with EC50 of 270 nM, 110 nM and 70 nM.
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