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Apatinib (YN968D1)
Cat No.
CEI-0028
Description
Apatinib (YN968D1)
CAS No.
811803-05-1
Molecular Weight
493.58
Purity
>99%
Storage
2 years at -20 centigrade
Targets
VEGFR2
Molecular Formula
C25H27N5O4S
Solubility
No
In vitro
Apatinib (YN968D1) can selectively inhibit VEGFR2 with IC50 of 1 nM. Apatinib effectively inhibits proliferation, migration and tube formation of human umbilical vein endothelial cells induced by FBS, and blocked the budding of rat aortic ring. Apatinib reverses ABCB1- and ABCG2-mediated MDR by inhibiting their transport function, but not by blocking the AKT or ERK1/2 pathway or downregulating ABCB1 or ABCG2 expression.
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