An inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC50 = 17.5 µM) and Raji cells (IC50 = 2.8µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
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