Description
Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM. Aliskiren hemifumarate can bind to both the hydrophobic S1/S3-binding pocket and to a large, distinct subpocket that extends from the S3-binding site towards the hydrophobic core of renin. Oral bioavailability of Aliskiren hemifumarate is 2.4% in rats, 16% in marmosets and about 2.5% in humans.
Storage
2 years at -20centigrade Powder
Molecular Formula
C30H53N3O6.1/2C4H4O4
Chemical Name
(2S,4S,5S,7S)-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hemifumarate
Solubility
DMSO 122 mg/mL, Water 122 mg/mL, Ethanol 122 mg/mL
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