Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
AG-879
Cat No.
CEI-0956
Description
Inhibits NGF receptor tyrosine kinase (TrkA, pp140trk). Inhibits NGF-induced neurite outgrowth in PC12 cells. Displays antitumor activity in a mouse model. Blocks the ETK-PAK1 interaction, suppressing RAS-induced PAK1 activation and malignant transformation. Cell permeable.
Abbr
AG-879(NGFR)
Alias
alpha-Cyano-(3, 5-di-t-butyl-4-hydroxy)thiocinnamide
Appearance
Yellow powder
Product Overview
NGFR inhibitor
CAS No.
148741-30-4
Molecular Weight
316.5
Purity
>99% (TLC); NMR (Conforms)
Synonyms
alpha-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
Targets
NGFR
Molecular Formula
C18H24N2OS
Melting Point
223-224ºC
Solubility
May be dissolved in DMSO (25mg/ml) or Ethanol (20 mg/ml)
Download
Download Datasheet