Description
Adenosine deaminase is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Present in virtually all mammalian cells, its primary function in Humans is the development and maintenance of the immune system.
Abbr
ADA, Recombinant (Bovine)
Alias
ADA; adenosine deaminase
Applications
Adenosine deaminase is useful in various molecular biology assays, such as glycerol release assays. Adenosine deaminase is a potential target for treatments of combined immunodeficiency disease.
Product Overview
Protein determined by biuret.
Form
ammonium sulfate suspension. Suspension in 3.2 M (NH4)2SO4, 0.01 M potassium phosphate, pH 6.0
Enzyme Commission Number
EC 3.5.4.4
Activity
60-130 units/mg protein; > 130 units/mg protein; 150-200 units/mg protein
Molecular Weight
32.5-33 kDa
Unit Definition
One unit will deaminate 1.0 μmole of adenosine to inosine per min at pH 7.5 at 25°C.
Pathway
Metabolic pathways, organism-specific biosystem; Primary immunodeficiency, organism-specific biosystem; Purine metabolism, conserved biosystem
Function
adenosine deaminase activity; protein binding; zinc ion binding
Synonyms
ADA; adenosine deaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4
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