Alias
Aciclovir, Acycloguanosine, Zovirax
Storage
2 years at -20centigrade Powder
Synonyms
Aciclovir, Acycloguanosine, Zovirax
Molecular Formula
C8H11N5O3
Solubility
DMSO 45 mg/mL,Water
In vitro
Acyclovir is a synthetic nucleoside analogue active against herpesviruses. It is a guanosine analogue antiviral drug. Aciclovir differs from previous nucleoside analogues in that it contains only a partial nucleoside structure: the sugar ring is replaced by an open-chain structure. It is selectively converted into acyclo-guanosine monophosphate (acyclo-GMP) by viral thymidine kinase, which is far more effective (3000 times) in phosphorylation than cellular thymidine kinase.
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