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A-769662

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Cat No.

CEI-0133

Description

A-769662 can inhibit AMPK, AMPK alpha-1,AMPK beta-1, and AMPK gamma-1 with IC50 of 0.8 mM, 0.7 mM, 0.7 mM, and 0.7 mM.

CAS No.

844499-71-4

Molecular Weight

360.39

Purity

>99%

Storage

2 years at -20centigrade Powder

Targets

AMP, AMPK alpha-1, AMPK beta-1, AMPK gamma-1

Molecular Formula

C20H12N2O3S

Chemical Name

Thieno[2,3-b]pyridine-5-carbonitrile, 6,7-dihydro-4-hydroxy-3-(2-hydroxy[1,1-biphenyl]-4-yl)-6-oxo-

Solubility

DMSO 72 mg/mL Water

In vitro

As an AMPK activators, A-769662 activates AMPK with EC 50 of 0.8 mM. A-769662 was equally potent in activating the baculovirus expressed alpha-1,beta-1,gamma-1 recombinant isoform of AMPK with EC50 of 0.7 mM. A-769662-induced AMPK activation occurs by reversible binding.

In vivo

Since AMPK activation inhibits ACC activity, there is a decrease in malonyl CoA levels, leading to reduced lipogenesis and increased fatty acid oxidation.

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-1004	Recombinant Adenine phosphoribosyltransferase from E. coli	EC 2.4.2.7	9027-80-9	E. coli	Inquiry
NATE-1005	Recombinant Adenine phosphoribosyltransferase from Thermus thermophilus	EC 2.4.2.7	9027-80-9	E. coli	Inquiry