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S-methyl-5'-thioadenosine phosphorylase from Human, Recombinant
Cat No.
NATE-0462
Description
MTAP expression is crucial for the catabolism of methylthioadenosine, which is a by-product of polyamine biosynthesis in the methionine salvage pathway. Protein expression is decreased by homozygous deletion and promoter hypermethylation.
Abbr
MTAP, Recombinant (Human)
Alias
MTAP
Source
E. coli
Species
Human
Applications
S-methyl-5′-thioadenosine phosphorylase human (MTAP) is an enzyme used in cancer research that is deficient in many types of cancer. Decreased MTAP expression may be used as a potential indicator of disease progression of gastrointestinal stromal tumors. MTAP may be a used to develop potential therapeutic strategies for hepat ocellular carcinoma (HCC) since MTAP inactivation has been linked to HCC development and invasiveness
Product Overview
N-terminal GST-tagged 57 kDa protein containing amino acids 2-end.
Form
Supplied as a solution in 25 mM Tris-HCl, pH 8.0,100 mM NaCl, 0.05% Tween-20, 10% glycerol,and 3 mM DTT.
Enzyme Commission Number
EC 2.4.2.28
CAS No.
61970-06-7
Molecular Weight
57 kDa
Storage
−70°C
Synonyms
S-methyl-5'-thioadenosine phosphorylase; EC 2.4.2.28; 5'-deoxy-5'-methylthioadenosine phosphorylase; MTA phosphorylase; MeSAdo phosphorylase; MeSAdo/Ado phosphorylase; methylthioadenosine phosphorylase; methylthioadenosine nucleoside phosphorylase; 5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase; S-methyl-5-thioadenosine phosphorylase; S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-α-D-ribosyl-transferase; MTAP
Download
Download Datasheet| Catalog | Product Name | EC No. | CAS No. | Source | Price |
|---|---|---|---|---|---|
| EXWM-2655 | S-methyl-5'-thioadenosine phosphorylase | EC 2.4.2.28 | 61970-06-7 | Inquiry |