Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
Protein Kinase G Iβ human, Recombinant
Cat No.
NATE-0580
Description
Protein Kinase G Iβ induces apoptosis in certain cell lines such as human breast cancer cell lines MCF-7 and MDA-MB-468. It inhibits cell proliferation and induces apoptosis in colon cancer cell lines.
Abbr
PKG1B, Recombinant (Human)
Alias
PRKG1B; PRKGR1B; PKG1B
Source
baculovirus infected insect cells
Species
Human
Applications
Protein Kinase G is a serine/threonine-specific protein kinase that is activated by cGMP. Protein Kinase G Iβ is used to induce apoptosis and inhibit cell proliferation.
Product Overview
> 95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf9 cells, buffered aqueous glycerol solution
Form
buffered aqueous glycerol solution
Activity
> 1.5 units/mg protein (20-fold stimulation by cGMP (5 μM))
Molecular Weight
mol wt 76 kDa (monomer)
Purity
>95% (SDS-PAGE)
Unit Definition
One unit will phosphorylate 1 micromole of VASPtide (RRKVSKQE) substrate per minute in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 1 mM DTE and 0.2 mM EDTA.
Stability
−20°C
Buffer
Solution in 20 mM Tris buffer, pH 7.4, 1 mM EDTA, 1 mM β-mercaptoethanol, 100 mM NaCl, 10 U/ml Trasylol, and 50% glycerol.
Pathway
Adaptive Immune System, organism-specific biosystem; Gap junction, organism-specific biosystem; Gap junction, conserved biosystem; Hemostasis, organism-specific biosystem; Immune System, organism-specific biosystem; Long-term depression, organism-specific biosystem; Long-term depression, conserved biosystem
Function
ATP binding; cGMP binding; cGMP-dependent protein kinase activity; calcium channel regulator activity; nucleotide binding; protein binding; protein serine/threonine kinase activity
Synonyms
Protein Kinase G Iβ; PRKG1B; PRKGR1B; PKG1B; cGMP-dependent protein kinase 1; cGKI-BETA
Download
Download Datasheet| Catalog | Product Name | EC No. | CAS No. | Source | Price |
|---|---|---|---|---|---|
| NATE-0581 | Protein Kinase G II from rat, Recombinant | baculovirus infected Sf9 cells | Inquiry |