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Acyl-Coenzyme A Dehydrogenase 8 from Human, Recombinant
Cat No.
NATE-0801
Description
Acyl CoA dehydrogenase is the enzymeused to catalyzethe first step of β-oxidationin Fatty acid metabolism. Acyl-coenzyme A (CoA) dehydrogenases (ACADs) are a family of mitochondrial enzymes that catalyze the first dehydrogenation step in the bets-oxidation of fatty acyl-CoA derivatives. Several human ACADs exist and all ACADs catalyze the same initial dehydrogenation of the substrate at the beta-carbon atom and require electron transfer flavoprotein as an alectron acceptor. The predicted 415-amino acid ACAD8 protein contains many of the residues conserved in most other ACADs, including an active site glutamic acid residue and residues important for tetramer formation.
Abbr
ACAD-8, Recombinant (Human)
Alias
ACAD-8
Source
E. coli
Species
Human
Applications
ELISA; MS; Inhibition Assays; Western Blotting
Appearance
Sterile Filtered clear solution.
Product Overview
Acyl-Coenzyme A Dehydrogenase 8 Human Recombinant produced in E. coli is a nonglycosylated, polypeptide chain containing amino acids 1-415 and having a total molecular mass of 47.7 kda. ACAD8 contains T7 tag at the N-terminus. ACAD-8 is purified by proprietary chromatographic techniques.
Molecular Weight
47.7 kDa
Purity
Greater than 95.0% as determined by SDS-PAGE.
Stability
ACAD8 although stable at 4°C for 1 week, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Buffer
Acyl-Coenzyme A Dehydrogenase 8 at a concentration of 0.1mg/ml in 10mM Tris, Ph 8.0, 0.1% Triton X-100, 0.002% NaN3, 10mM DTT.
Synonyms
Acyl-CoA dehydrogenase family member 8 mitochondrial; ACAD-8; Isobutyryl-CoA dehydrogenase; Activator-recruited cofactor 42 kDa component; ARC42; FLJ22590
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